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KMID : 0811820080120020143
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Journal of Korean Society of Pediatric Nephrology
2008 Volume.12 No. 2 p.143 ~ p.149
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Urinary N-Acetyl-beta-D-Glucosaminidase and beta 2-Microglobulin in Children with Various Renal Diseases
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Yoon So-Jin
Kim Hyon-Suk
Lee Jae-Seung
Shin Jae-Il
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Abstract
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Purpose : Urinary N-acetyl-beta-D-glucosaminidase(NAG) and beta 2-microglobulin(B2M) is considered to be a marker of tubulointerstitial injury. The aim of this study was to examine the urinary levels of NAG and B2M in children with various renal diseases.
Methods : We studied 21 children(8.94.5 years, Male:Female=14:7) and they were divided into three groups: group I(steroid-sensitive nephrotic syndrome-4 patients), group II(various kinds of glomerulonephritis-4 patients), and group III(normal urinalysis or non-glomerular renal diseases-13 patients).
Results : Urinary NAG levels in groups I and II were significantly higher than those in group III(19.411.5 and 30.030.1 vs. 4.73.9, P=0.01), while urinary B2M levels did not differ among the 3 groups, although urinary NAG levels were positively correlated with urinary B2M levels(r=0.49, P=0.03). Urinary NAG and B2M levels were all correlated with proteinuria(r=0.79, P<0.001 and r=0.68, respectively, P=0.001) serum albumin(r=-0.72, P<0.001 and r=-0.57, respectively, P=0.01) and cholesterol(r=0.58, P=0.006 and r=0.56, respectively, P=0.013) levels.
Conclusions : Urinary excretions of NAG and B2M are increased in children with steroidsensitive nephrotic syndrome and various kinds of glomerulonephritis, suggesting tubular dysfunction might be present in these diseases.
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KEYWORD
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N-acetyl-beta-D-glucosaminidase, Beta 2-microglobulin, Tubulointerstitial injury, Children
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